Background
Xeroderma Pigmentosum
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XPC and RAD4
XPC
The protein XPC plays a pivotal role in the nucleotide excision repair process by recognizing a broad spectrum of DNA lesions. Its function is vital for the efficient repair of DNA damages, ensuring genomic stability. Mutations in the XPC gene compromise this repair mechanism, significantly increasing the risk of developing conditions like Xeroderma Pigmentosum, which is marked by an increased susceptibility to skin cancers due to impaired DNA repair capabilities. |
RAD4
The RAD4 protein, through its kinetic gating mechanism of DNA damage recognition, showcases a refined method of distinguishing between damaged and undamaged DNA. This process is crucial for the nucleotide excision repair pathway, highlighting the sophistication of cellular mechanisms in maintaining genomic integrity. RAD4's selective recognition of DNA lesions ensures that repair processes are precisely targeted, minimizing the risk of genomic instability and associated disorders. |
Refrences
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Cluster Map
This web page was produced as an assignment for Genetics 564, a capstone course at UW-Madison.